SAN FRANCISCO — Nancy Pelosi, the trailblazing first female speaker of the House, has announced she will not seek reelection, marking the end of an influential political tenure. Pelosi, who has served since 1987, cited a desire to conclude her service with gratitude and pride in a heartfelt video to her constituents.

Under her leadership, Pelosi faced formidable challenges and made significant legislative impacts, including her staunch defense of the Affordable Care Act. Her decision to step down follows intensified speculation due to her recent primary challengers and personal hardships, including a violent home intrusion in 2022 and a hip replacement surgery last year.

Pelosi's announcement comes shortly after California's approval of a Democratic-favoring redistricting measure, sparking intense campaigning for her open seat. Prominent figures like Saikat Chakrabarti, a progressive tech mogul, and state lawmaker Scott Wiener have already shown interest, alongside city supervisor Connie Chan.

Despite her stepping back, Pelosi's influence remains palpable. She has actively campaigned for key Democratic initiatives and continues to be a strategic advisor to party leaders, exemplifying her enduring clout in national politics.

Her retirement not only signals a pivotal shift for San Francisco's political landscape but also poses significant implications for her senior Democratic colleagues in Washington, D.C., as they navigate the future without one of their most iconic figures. Pelosi's career has been marked by her resilience and dedication to liberal causes, often making her a central figure of Republican criticism.

As Pelosi prepares to leave a void in both her city and the Democratic Party, her legacy as a formidable and consequential leader is assured. Her efforts have not only shaped legislative battles but have also left an indelible mark on the political fabric of America.